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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PTPN7
All Species:
27.27
Human Site:
T127
Identified Species:
75
UniProt:
P35236
Number Species:
8
Phosphosite Substitution
Charge Score:
0.13
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P35236
NP_002823.2
360
40529
T127
A
S
K
D
R
Y
K
T
I
L
P
N
P
Q
S
Chimpanzee
Pan troglodytes
XP_001140385
339
38349
D125
G
R
A
Q
S
Q
E
D
G
D
Y
I
N
A
N
Rhesus Macaque
Macaca mulatta
XP_001106613
465
52305
T232
A
S
K
D
R
Y
K
T
I
L
P
N
P
Q
S
Dog
Lupus familis
XP_848933
360
40306
T127
A
S
K
D
R
Y
K
T
I
L
P
N
P
Q
S
Cat
Felis silvestris
Mouse
Mus musculus
Q8BUM3
359
40332
T127
A
S
K
D
R
Y
K
T
I
L
P
N
P
Q
S
Rat
Rattus norvegicus
P49445
359
40295
T127
A
S
K
D
R
Y
K
T
I
L
P
N
P
Q
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508421
480
53288
T248
A
S
K
D
R
Y
K
T
I
L
P
N
P
Q
S
Chicken
Gallus gallus
XP_001232669
363
40663
T130
A
S
K
D
R
Y
K
T
I
L
P
N
P
E
S
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_687962
521
58630
I287
R
K
N
R
Y
K
T
I
L
P
N
T
H
S
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
93.8
76.3
92.5
N.A.
92.2
91.3
N.A.
61.6
67.4
N.A.
36.2
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
93.8
76.5
94.4
N.A.
95
93.6
N.A.
66.2
78.7
N.A.
46.2
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
0
100
100
N.A.
100
100
N.A.
100
93.3
N.A.
0
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
13.3
100
100
N.A.
100
100
N.A.
100
100
N.A.
6.6
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
78
0
12
0
0
0
0
0
0
0
0
0
0
12
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
78
0
0
0
12
0
12
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
12
0
0
0
0
0
0
12
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
12
0
0
0
0
0
0
0
12
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
12
0
0
% H
% Ile:
0
0
0
0
0
0
0
12
78
0
0
12
0
0
0
% I
% Lys:
0
12
78
0
0
12
78
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
0
0
0
0
0
12
78
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
12
0
0
0
0
0
0
0
12
78
12
0
12
% N
% Pro:
0
0
0
0
0
0
0
0
0
12
78
0
78
0
0
% P
% Gln:
0
0
0
12
0
12
0
0
0
0
0
0
0
67
0
% Q
% Arg:
12
12
0
12
78
0
0
0
0
0
0
0
0
0
12
% R
% Ser:
0
78
0
0
12
0
0
0
0
0
0
0
0
12
78
% S
% Thr:
0
0
0
0
0
0
12
78
0
0
0
12
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
12
78
0
0
0
0
12
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _